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Thyroid glands from all surviving F 0 mother and father had been examined microscopically, and mind measurements had been carried out on all exposed F 1 pups and people F 1 pups selected for behavioural testing. There were no vital intercourse variations. In females, a greater proportion was excreted as sulfate conjugate, whereas males excreted the next proportion of a diconjugate both sulfate and glucuronide teams. From these knowledge, the authors concluded that male rats have a better capability for glucuronidation than females.
The organisms were exposed to the check concentrations for 96 h. Biological observations have been carried out day by day.
For the benthic and terrestrial compartments, the obtainable toxicity information cannot be thought to be sufficient for a quantitative danger characterization. However, these compartments are much less relevant for resorcinol, due to marginal releases and emissions to these compartments as well as a very low potential for adsorption of resorcinol to organic matter.
In basic, the h LC 50 values for resorcinol have been in the range between In move-by way of exams and analytical monitoring, DeGraeve et al. As talked about in section 9. Complete healing was famous after about 1 week of absence from work. However, with rising resorcinol concentrations, there was also a rise within the variety of individuals who tested optimistic. Resorcinol was also tested in hairdressers, who may have been in touch with resorcinol-containing hair dyes.


One issue increasing potential poisonous effects is the appliance of resorcinol to injured pores and skin Cassano et al. Surviving F zero parental and F 1 following selection rats underwent complete gross necropsy following the breeding period seven F zero males per group , following completion of weaning of F 1 pups F 0 females , following scheduled necropsy of F zero females remaining seven F zero males per group , on PND 28 F 1 exposed pups , or on PND 30 or 70 F 1 pups selected for behavioural testing.
In apply, nevertheless, the incidence of sensitization appears to be low. In animal research, the toxicological effects reported to be caused by administration of resorcinol include thyroid dysfunction, irritation to pores and skin and eyes, CNS results, and altered adrenal gland relative weights. After topical use of high concentrations of resorcinol, CNS disturbances, corresponding to dizziness, vertigo, confusion, disorientation, amnesia, or tremors, or purple blood cell changes, similar to methaemoglobinaemia, haemolytic anaemia, haemoglubinuria, or cyanosis, have been reported. One factor growing potential toxic results is the applying of resorcinol to injured skin.
The elimination was biphasic, with half-lives of 18—21 min and 8. The 14 C activity was rapidly distributed in major tissues similar to muscles, kidneys, and liver, without indication of bioaccumulation Merker et al. Any new data being offered in the midst of the OECD assessment might be provided to the IPCS in order that an addendum may be ready for consideration.

In both species, there were no adverse results on ultimate mean body weights, haematology, or clinical chemistry parameters, and no chemical-associated gross or microscopic lesions were observed. In one other study, rats had been exposed to 0 or 0. No thyroid hormone measurements have been performed.
Two long-time period research with Swiss mice or NZW rabbits, where the animals had been treated with zero. In an in vitro. In an investigation in three human volunteers utilizing conditions just like those utilized in hair dyeing, 14 C-ring-labelled 1. This means that only a small quantity of resorcinol penetrates the pores and skin during the actual means of hair colouring.
British Journal of Industrial Medicine , Toxicologic Pathology , Toxicology and Applied Pharmacology , Arnott DG, Doniach I The impact of compounds allied to resorcinol upon the uptake of radioactive iodine I by the thyroid of the rat. IARC evaluated the carcinogenicity of resorcinol in and concluded that there are no epidemiological data relevant to the carcinogenicity of resorcinol in people and that the proof of its carcinogenicity in animals is inadequate; thus, resorcinol isn't classifiable as to its carcinogenicity to humans. JECFA assessed the hazards from using resorcinol as a meals flavouring agent and concluded that this use is of no safety concern. Overall, the studies are not adequate for a statistical extrapolation approach based on the EU Technical Guidance Document EC, a.


Animals were maintained for a number of months with periodic sacrifices Flickinger, The animals have been then examined weekly for 10 further weeks. Sacrificed animals showed brown-dyed abdomen walls and filling of stomach and small gut with a darkish-brown to orange substance. These findings weren't noted in survivors.


In rodents, the higher sensitivity is also related to a shorter plasma half-lifetime of T 4 than in humans as a result of appreciable differences between species within the transport proteins for thyroid hormones. In plasma, the T four half-life is about 12—24 h in rats vs 5—9 days in people, and the serum ranges of TSH are about 25 occasions greater in rodents than in people.
In in vitro genotoxicity tests, resorcinol showed largely unfavorable results. Results from all reported in vivo checks for genotoxicity have been negative. Mostly negative results were reported in the initiation—promotion research carried out using a number of species. UV irradiation triggered no elevated pores and skin reactions. The iodination course of is catalysed by a haem-containing enzyme.

In in vitro human pores and skin studies, resorcinol was evaluated from a representative hair dye formulation that contained 0. However, it ought to be considered that acned skin could also be broken due either to scratching or to the blemishes themselves.